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#1 von xuezhiqian123 , 15.01.2020 06:49

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The correct selection of materials requires an understanding of the relationships existing between structure and properties. Therefore, materials have to be used in a correct and appropriate way, in accordance with the natural characteristic of the material that can be exploited and enhanced.


How can such concepts be applied to the development of new products? The evolutionary approach to this problem (Fig. 1) makes it possible to achieve new features capable of improving the system as a whole.


An Evolutionary Design Biomedical Case Study: Biomechanics and Biomimetics to Foster advanced Materials and Technologies Potentials


Bone implants are expected to serve for much longer period or until lifetime without failure or revision surgery (Burnstein et al. Xavien Howard Youth Jersey , 1976; Oh and Harris, 1976; Rohlmann et al., 1982; Reilly and Burstein 1974; Reilly and Burnestain, 1975). Thus, design and development of appropriate combination of material and prosthetic systems with high longevity and improved biocompatibility is highly essential (Ashman et al., 1984; Ashman and Rho 1988; Kummer Laremy Tunsil Youth Jersey , 1986; Gottesman and Hashin, 1980; Annunziata et al., 2006, Dalstyra et al., 1993).


Figure 1 shows the design driven path for the combined material and product evolutionary development. This path is a combination of several combined research, industrial and theoretical activities (Fig. 2) such as biomimetic new hybrid ceramo-polymeric material development (Schiraldi et al. Raekwon McMillan Youth Jersey , 2004; Aversa et al., 2016a; 2016b; 2016c, Gramanzini et al., 2016) (Fig. 3), maximum exploitation of potentialities of the additive manufacturing in new production 聽(Aversa et al 2016a) (Fig. 4) and highly non-linear biofidel modeling of bone mechanical modeling, in silico Jason Sanders Youth Jersey , in vitro and in vivo tests (Fig. 5) (Aversa et al., 2009,; Apicella et al., 2010).








If an implant fractures due to inadequate strength or mismatch in mechanical property between the bone and implant, then this is referred to as biomechanical incompatibility. The material replaced for bone is expected to have an “equivalent stiffness” (combination of material elastic modulus and prosthesis shape) matching that of bone area where it is implanted. The bone modulus varies in the magnitude from 4 to 30 GPa depending on the type of the bone and the direction of measurement. The current implant materials which have higher stiffness than bone, strongly alters the physiological bone stress distribution and prevents the needed stress being transferred to adjacent bone Jerome Baker Youth Jersey , resulting in bone reabsorption around the implant and consequently to implant loosening (Sorrentino et al., 2007; Beaupre and Hayes, 1985; Carter and Hayes, 1977; Perillo et al., 2010).


This biomechanical incompatibility that leads to death of bone cells is called as ‘‘stress shielding effect”. Thus, a customized material with excellent combination of high strength and stiffness matching that of the bone has to be used for biomechanical integrated implantation to avoid loosening of implants and higher service period to avoid revision surgery (Apicella et al. Mike Gesicki Youth Jersey , sa et al., 2016a; 2016b; 2016c).


The metal part of the new prosthesis will be made of titanium alloy using the Electron Beam Melting (EBM) technology.



The biological part of the project (hybrid ceramo polymeric material) aims to provide a new type of biocompatible and biodegradable material suitable for being formed into porous structures such as three-dimensional scaffold (Petrescu et al., 2015).


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